A little girl's brother kills the whole family but her (she escapes by hiding in the basement). He is committed, and she grows up with a new family, eventually going to college, where she joins a sorority. Due to a memory block, she doesn't remember that the sorority house was her childhood house. Her brother senses her presence in the house and escapes so he can finish the job he was unable to complete.

Beth (Angela O'Neill), a girl with a mysterious past, moves into her new sorority just as most of the other girls are leaving for Memorial Day weekend. Once settled, Beth begins to remember things from her childhood -- including the fact the sorority house used to be her home. It's also where her little brother murdered everyone else in her family. In a nearby asylum, Beth's brother learns she's back and begins planning his finale.